Heparan sulfate proteoglycans

S Sarrazin, WC Lamanna… - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
S Sarrazin, WC Lamanna, JD Esko
Cold Spring Harbor perspectives in biology, 2011cshperspectives.cshlp.org
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of ligands. Over the last decade, new insights have
emerged regarding the mechanism and biological significance of these interactions. Here,
we discuss changing views on the specificity of protein–heparan sulfate binding and the
activity of HSPGs as receptors and coreceptors. Although few in number, heparan sulfate
proteoglycans have profound effects at the cellular, tissue, and organismal level.
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding the mechanism and biological significance of these interactions. Here, we discuss changing views on the specificity of protein–heparan sulfate binding and the activity of HSPGs as receptors and coreceptors. Although few in number, heparan sulfate proteoglycans have profound effects at the cellular, tissue, and organismal level.
cshperspectives.cshlp.org