Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro
S Plantman, M Patarroyo, K Fried… - Molecular and Cellular …, 2008 - Elsevier
A prerequisite for axon regeneration is the interaction between the growth cone and the
extracellular matrix (ECM). Laminins are prominent constituents of ECM throughout the
body, known to support axon growth in vitro and in vivo. The regenerative capacity of adult
neurons is greatly diminished compared to embryonic or early postnatal neurons. Since
most lesions in the nervous system occur in the adult, we have examined neurite outgrowth
from adult mouse DRG neurons on four laminin isoforms (laminin-1/LM-111, laminin-2/LM …
extracellular matrix (ECM). Laminins are prominent constituents of ECM throughout the
body, known to support axon growth in vitro and in vivo. The regenerative capacity of adult
neurons is greatly diminished compared to embryonic or early postnatal neurons. Since
most lesions in the nervous system occur in the adult, we have examined neurite outgrowth
from adult mouse DRG neurons on four laminin isoforms (laminin-1/LM-111, laminin-2/LM …