[HTML][HTML] Folding and function of I domain-deleted Mac-1 and lymphocyte function-associated antigen-1
P Yalamanchili, C Lu, C Oxvig, TA Springer - Journal of Biological …, 2000 - ASBMB
In those integrins that contain it, the I domain is a major ligand recognition site. The I domain
is inserted between β-sheets 2 and 3 of the predicted β-propeller domain of the integrin α
subunit. We deleted the I domain from the integrin α M and α L subunits to give I-less Mac-1
and lymphocyte function-associated antigen-1 (LFA-1), respectively. The I-less α M and α L
subunits were expressed in association with the wild-type β 2 subunit on the surface of
transfected cells and bound to all the monoclonal antibodies mapped to the putative β …
is inserted between β-sheets 2 and 3 of the predicted β-propeller domain of the integrin α
subunit. We deleted the I domain from the integrin α M and α L subunits to give I-less Mac-1
and lymphocyte function-associated antigen-1 (LFA-1), respectively. The I-less α M and α L
subunits were expressed in association with the wild-type β 2 subunit on the surface of
transfected cells and bound to all the monoclonal antibodies mapped to the putative β …