UCSF Chimera, MODELLER, and IMP: an integrated modeling system

Z Yang, K Lasker, D Schneidman-Duhovny… - Journal of structural …, 2012 - Elsevier
Structural modeling of macromolecular complexes greatly benefits from interactive
visualization capabilities. Here we present the integration of several modeling tools into
UCSF Chimera. These include comparative modeling by MODELLER, simultaneous fitting of
multiple components into electron microscopy density maps by IMP MultiFit, computing of
small-angle X-ray scattering profiles and fitting of the corresponding experimental profile by
IMP FoXS, and assessment of amino acid sidechain conformations based on rotamer …