[HTML][HTML] The histone demethylase UTX promotes brown adipocyte thermogenic program via coordinated regulation of H3K27 demethylation and acetylation

L Zha, F Li, R Wu, L Artinian, V Rehder, L Yu… - Journal of Biological …, 2015 - ASBMB
Brown adipocytes function to dissipate energy as heat through adaptive thermogenesis.
Understanding the molecular mechanisms underlying the brown fat thermogenic program
may provide insights for the development of therapeutic approaches in the treatment of
obesity. Most studies investigating the mechanisms underlying brown fat development focus
on genetic mechanisms; little is known about the epigenetic mechanisms in this process. We
have discovered that ubiquitously transcribed tetratricopeptide repeat on chromosome X …