Productive HIV-1 infection of primary CD4+ T cells induces mitochondrial membrane permeabilization leading to a caspase-independent cell death
F Petit, D Arnoult, JD Lelievre… - Journal of Biological …, 2002 - ASBMB
We have explored in vitrothe mechanism by which human immunodeficiency virus, type 1
(HIV-1) induces cell death of primary CD4+ T cells in conditions of productive infection.
Although HIV-1 infection primed phytohemagglutinin-activated CD4+ T cells for death
induced by anti-CD95 antibody, T cell death was not prevented by a CD95-Fc decoy
receptor, nor by decoy receptors of other members of the TNFR family (TNFR1/R2,
TRAILR1/R2/OPG, TRAMP) or by various blocking antibodies, suggesting that triggering of …
(HIV-1) induces cell death of primary CD4+ T cells in conditions of productive infection.
Although HIV-1 infection primed phytohemagglutinin-activated CD4+ T cells for death
induced by anti-CD95 antibody, T cell death was not prevented by a CD95-Fc decoy
receptor, nor by decoy receptors of other members of the TNFR family (TNFR1/R2,
TRAILR1/R2/OPG, TRAMP) or by various blocking antibodies, suggesting that triggering of …
