Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—an emerging role for gut microbiome
Introduction Increasing evidence suggests a role for the gut microbiome in central nervous
system disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids
(BAs), products of cholesterol metabolism and clearance, are produced in the liver and are
further metabolized by gut bacteria. They have major regulatory and signaling functions and
seem dysregulated in Alzheimer's disease (AD). Methods Serum levels of 15 primary and
secondary BAs and their conjugated forms were measured in 1464 subjects including 370 …
system disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids
(BAs), products of cholesterol metabolism and clearance, are produced in the liver and are
further metabolized by gut bacteria. They have major regulatory and signaling functions and
seem dysregulated in Alzheimer's disease (AD). Methods Serum levels of 15 primary and
secondary BAs and their conjugated forms were measured in 1464 subjects including 370 …
