Antimicrobial activity of exebacase (lysin CF-301) against the most common causes of infective endocarditis
Antimicrobial Agents and Chemotherapy, 2019•Am Soc Microbiol
Exebacase, a recombinantly produced lysin (cell wall hydrolase), and comparator antibiotics
were tested by the broth microdilution method against strain sets of Staphylococcus and
Streptococcus spp., which are the most common causes of infective endocarditis in humans.
Exebacase was active against all Staphylococcus spp. tested, including S. aureus and
coagulase-negative staphylococci (MIC50/90, 0.5/1 μg/ml). Activity against Streptococcus
spp. was variable, with S. pyogenes, S. agalactiae, and S. dysgalactiae (MIC50/90, 1/2 …
were tested by the broth microdilution method against strain sets of Staphylococcus and
Streptococcus spp., which are the most common causes of infective endocarditis in humans.
Exebacase was active against all Staphylococcus spp. tested, including S. aureus and
coagulase-negative staphylococci (MIC50/90, 0.5/1 μg/ml). Activity against Streptococcus
spp. was variable, with S. pyogenes, S. agalactiae, and S. dysgalactiae (MIC50/90, 1/2 …
Abstract
Exebacase, a recombinantly produced lysin (cell wall hydrolase), and comparator antibiotics were tested by the broth microdilution method against strain sets of Staphylococcus and Streptococcus spp., which are the most common causes of infective endocarditis in humans. Exebacase was active against all Staphylococcus spp. tested, including S. aureus and coagulase-negative staphylococci (MIC50/90, 0.5/1 μg/ml). Activity against Streptococcus spp. was variable, with S. pyogenes, S. agalactiae, and S. dysgalactiae (MIC50/90, 1/2 μg/ml) among the most susceptible.
American Society for Microbiology