Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury
Spinal cord injury (SCI) is a devastating traumatic injury that causes persistent, severe motor
and sensory dysfunction. Immune responses are involved in functional recovery after SCI.
Mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) has been shown to
regulate the survival and differentiation of immune cells and to play a critical role in many
diseases, but its function in lesion recovery after SCI remains unclear. In this paper, we
generated KI (knock in) mice with a point mutation (C472G) in the active center of MALT1 …
and sensory dysfunction. Immune responses are involved in functional recovery after SCI.
Mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) has been shown to
regulate the survival and differentiation of immune cells and to play a critical role in many
diseases, but its function in lesion recovery after SCI remains unclear. In this paper, we
generated KI (knock in) mice with a point mutation (C472G) in the active center of MALT1 …