[HTML][HTML] Mechanisms of tissue injury in lupus nephritis
TK Nowling, GS Gilkeson - Arthritis research & therapy, 2011 - Springer
TK Nowling, GS Gilkeson
Arthritis research & therapy, 2011•SpringerSystemic lupus erythematosus is a prototypic autoimmune disease characterized by
autoantibody production and immune complex formation/deposition in target organs such as
the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major
cause of morbidity and mortality in patients with lupus, occurs in approximately 50% of lupus
patients. In the present review, we provide an overview of the current research and
knowledge concerning mechanisms of renal injury in both lupus-prone mouse models and …
autoantibody production and immune complex formation/deposition in target organs such as
the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major
cause of morbidity and mortality in patients with lupus, occurs in approximately 50% of lupus
patients. In the present review, we provide an overview of the current research and
knowledge concerning mechanisms of renal injury in both lupus-prone mouse models and …
Abstract
Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammation then leads to organ damage. Nephritis, a major cause of morbidity and mortality in patients with lupus, occurs in approximately 50% of lupus patients. In the present review, we provide an overview of the current research and knowledge concerning mechanisms of renal injury in both lupus-prone mouse models and human lupus patients.
Springer
