[HTML][HTML] Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms
PS Dalvi, A Singh, HR Trivedi, FD Ghanchi… - Annals of thoracic …, 2011 - journals.lww.com
BACKGROUND: The protease-antiprotease hypothesis proposes that inflammatory cells
and oxidative stress in chronic obstructive pulmonary disease (COPD) produce increased
levels of proteolytic enzymes (neutrophil elastase, matrix metalloproteinases [MMP]) which
contribute to destruction of parenchyma resulting in progressive decline in forced expiratory
volume in one second. Doxycycline, a tetracycline analogue, possesses anti-inflammatory
properties and inhibits MMP enzymes. OBJECTIVES: To assess the effect of 4 weeks …
and oxidative stress in chronic obstructive pulmonary disease (COPD) produce increased
levels of proteolytic enzymes (neutrophil elastase, matrix metalloproteinases [MMP]) which
contribute to destruction of parenchyma resulting in progressive decline in forced expiratory
volume in one second. Doxycycline, a tetracycline analogue, possesses anti-inflammatory
properties and inhibits MMP enzymes. OBJECTIVES: To assess the effect of 4 weeks …