[HTML][HTML] Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells: regulation by tumor necrosis factor-α and doxycycline
R Hanemaaijer, T Sorsa, YT Konttinen, Y Ding… - Journal of Biological …, 1997 - ASBMB
Neutrophil collagenase (matrix metalloproteinase-8 or MMP-8) is regarded as being
synthesized exclusively by polymorphonuclear neutrophils (PMN). However, in vivo MMP-8
expression was observed in mononuclear fibroblast-like cells in the rheumatoid synovial
membrane. In addition, we detected MMP-8 mRNA expression in cultured rheumatoid
synovial fibroblasts and human endothelial cells. Up-regulation of MMP-8 was observed
after treatment of the cells with either tumor necrosis factor-α (10 ng/ml) or phorbol 12 …
synthesized exclusively by polymorphonuclear neutrophils (PMN). However, in vivo MMP-8
expression was observed in mononuclear fibroblast-like cells in the rheumatoid synovial
membrane. In addition, we detected MMP-8 mRNA expression in cultured rheumatoid
synovial fibroblasts and human endothelial cells. Up-regulation of MMP-8 was observed
after treatment of the cells with either tumor necrosis factor-α (10 ng/ml) or phorbol 12 …