Doxycycline, a tetracycline antibiotic, is widely used in the field of dermatology for its antibiotic properties, anti‐inflammatory properties and good safety profile. Over the past decades, numerous studies have clarified some of the anti‐inflammatory mechanisms of doxycycline. In this review article, we aimed to provide an update on recent data on the anti‐inflammatory properties of doxycycline and its potential role in cutaneous inflammatory diseases. Better understanding of these mechanisms might offer the practicing clinicians a better use of this therapeutic tool. In addition, research in this field could help clarify pathogenic aspects of inflammatory dermatologic diseases responsive to this medication. Further research is needed to fully elucidate the potential of doxycycline as an anti‐inflammatory agent, and the development of new topical vehicles could open ways to new therapeutic possibilities for dermatologists.