Bispecific chimeric antigen receptors targeting the CD4 binding site and high-mannose Glycans of gp120 optimized for anti–human immunodeficiency virus potency …
MH Ghanem, S Bolivar-Wagers, B Dey, A Hajduczki… - Cytotherapy, 2018 - Elsevier
Background aims Chimeric antigen receptors (CARs) offer great potential toward a
functional cure of human immunodeficiency virus (HIV) infection. To achieve the necessary
long-term virus suppression, we believe that CARs must be designed for optimal potency
and anti-HIV specificity, and also for minimal probability of virus escape and CAR
immunogenicity. CARs containing antibody-based motifs are problematic in the latter regard
due to epitope mutation and anti-idiotypic immune responses against the variable regions …
functional cure of human immunodeficiency virus (HIV) infection. To achieve the necessary
long-term virus suppression, we believe that CARs must be designed for optimal potency
and anti-HIV specificity, and also for minimal probability of virus escape and CAR
immunogenicity. CARs containing antibody-based motifs are problematic in the latter regard
due to epitope mutation and anti-idiotypic immune responses against the variable regions …