Sortilin deficiency improves the metabolic phenotype and reduces hepatic steatosis of mice subjected to diet-induced obesity
L Rabinowich, S Fishman, E Hubel, T Thurm… - Journal of …, 2015 - Elsevier
Background & Aims Sortilin traffics newly synthesized molecules from the trans-Golgi
apparatus along secretory pathways to endosomes, lysosomes or to the cell surface. Sortilin
trafficking of acid sphingomyelinase (aSMase) may regulate ceramide levels, a major
modulator of insulin signalling. We therefore tested whether sortilin deficiency reduces
hepatic and adipose tissue aSMase activity, improving insulin sensitivity in diet-induced
obesity (DIO). Methods DIO in C57BL/6 (WT) and sortilin−/− mice was induced by high-fat …
apparatus along secretory pathways to endosomes, lysosomes or to the cell surface. Sortilin
trafficking of acid sphingomyelinase (aSMase) may regulate ceramide levels, a major
modulator of insulin signalling. We therefore tested whether sortilin deficiency reduces
hepatic and adipose tissue aSMase activity, improving insulin sensitivity in diet-induced
obesity (DIO). Methods DIO in C57BL/6 (WT) and sortilin−/− mice was induced by high-fat …
