[HTML][HTML] Targeting the tumor microenvironment: removing obstruction to anticancer immune responses and immunotherapy
JM Pitt, A Marabelle, A Eggermont, JC Soria… - Annals of …, 2016 - Elsevier
Annals of Oncology, 2016•Elsevier
The tumor microenvironment (TME) is an integral part of cancer. Recognition of the essential
nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of
cancer development to the concept of a complex tumor ecosystem that supports tumor
growth and metastatic dissemination. Accordingly, novel targets within the TME have been
uncovered that can help direct and improve the actions of various cancer therapies, notably
immunotherapies that work by potentiating host antitumor immune responses. Here, we …
nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of
cancer development to the concept of a complex tumor ecosystem that supports tumor
growth and metastatic dissemination. Accordingly, novel targets within the TME have been
uncovered that can help direct and improve the actions of various cancer therapies, notably
immunotherapies that work by potentiating host antitumor immune responses. Here, we …
Abstract
The tumor microenvironment (TME) is an integral part of cancer. Recognition of the essential nature of the TME in cancer evolution has led to a shift from a tumor cell-centered view of cancer development to the concept of a complex tumor ecosystem that supports tumor growth and metastatic dissemination. Accordingly, novel targets within the TME have been uncovered that can help direct and improve the actions of various cancer therapies, notably immunotherapies that work by potentiating host antitumor immune responses. Here, we review the composition of the TME, how this attenuates immunosurveillance, and discuss existing and potential strategies aimed at targeting cellular and molecular TME components.
Elsevier
