[HTML][HTML] Vesicular stomatitis virus–based vaccines against lassa and ebola viruses
A Marzi, F Feldmann, TW Geisbert… - Emerging infectious …, 2015 - ncbi.nlm.nih.gov
A Marzi, F Feldmann, TW Geisbert, H Feldmann, D Safronetz
Emerging infectious diseases, 2015•ncbi.nlm.nih.govWe demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)–based
Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-
based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines
against divergent viral pathogens, even when preexisting immunity to the vaccine vector is
present.
Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-
based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines
against divergent viral pathogens, even when preexisting immunity to the vaccine vector is
present.
Abstract
We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)–based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present.
ncbi.nlm.nih.gov
