Sirtuins are a family of NAD+-dependent protein deacetylases/deacylases that dynamically
regulate transcription, metabolism, and cellular stress response. Their general positive link
with improved health span in mammals, potential regulation of pathways mediated by caloric
restriction, and growing links to human disease have spurred interest in therapeutics that
target their functions. Here, we review the current understanding of the chemistry of
catalysis, biological targets, and endogenous regulation of sirtuin activity. We discuss recent …