The difference δ-cells make in glucose control
MO Huising, T van der Meulen, JL Huang… - …, 2018 - journals.physiology.org
MO Huising, T van der Meulen, JL Huang, MS Pourhosseinzadeh, GM Noguchi
Physiology, 2018•journals.physiology.orgThe role of beta and α-cells to glucose control are established, but the physiological role of δ-
cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to
modulate insulin and glucagon secretion at their source. We review the evidence for a
negative feedback loop between delta and β-cells that determines the blood glucose set
point and suggest that local δ-cell-mediated feedback stabilizes glycemic control.
cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to
modulate insulin and glucagon secretion at their source. We review the evidence for a
negative feedback loop between delta and β-cells that determines the blood glucose set
point and suggest that local δ-cell-mediated feedback stabilizes glycemic control.
The role of beta and α-cells to glucose control are established, but the physiological role of δ-cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We review the evidence for a negative feedback loop between delta and β-cells that determines the blood glucose set point and suggest that local δ-cell-mediated feedback stabilizes glycemic control.
American Physiological Society