[HTML][HTML] Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans
MJ Marakalala, AM Kerrigan, GD Brown - Mammalian Genome, 2011 - Springer
MJ Marakalala, AM Kerrigan, GD Brown
Mammalian Genome, 2011•SpringerThe clinical relevance of fungal infections has increased dramatically in recent decades as a
consequence of the rise of immunocompromised populations, and efforts to understand the
underlying mechanisms of protective immunity have attracted renewed interest. Here we
review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss
recent discoveries of polymorphisms in the gene encoding this receptor which result in
human disease.
consequence of the rise of immunocompromised populations, and efforts to understand the
underlying mechanisms of protective immunity have attracted renewed interest. Here we
review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss
recent discoveries of polymorphisms in the gene encoding this receptor which result in
human disease.
Abstract
The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
Springer