CARD9 Syk-dependent and Raf-1 Syk-independent signaling pathways in target recognition of Candida albicans by Dectin-1
H Yang, H He, Y Dong - European journal of clinical microbiology & …, 2011 - Springer
H Yang, H He, Y Dong
European journal of clinical microbiology & infectious diseases, 2011•SpringerAs a principle receptor to β-glucan in the Candida albicans cell wall, Dectin-1 performs
recognition specifically and its mechanisms are diverse in different situations. With a view to
developing certain antifungal targeted drugs, this review provides new insights into the
novel immune signaling pathways induced by Dectin-1, especially the novel understandings
of CARD9 in the Syk-dependent NF-κB pathway, and of Raf-1 in the Syk-independent NF-κB
signaling pathway.
recognition specifically and its mechanisms are diverse in different situations. With a view to
developing certain antifungal targeted drugs, this review provides new insights into the
novel immune signaling pathways induced by Dectin-1, especially the novel understandings
of CARD9 in the Syk-dependent NF-κB pathway, and of Raf-1 in the Syk-independent NF-κB
signaling pathway.
Abstract
As a principle receptor to β-glucan in the Candida albicans cell wall, Dectin-1 performs recognition specifically and its mechanisms are diverse in different situations. With a view to developing certain antifungal targeted drugs, this review provides new insights into the novel immune signaling pathways induced by Dectin-1, especially the novel understandings of CARD9 in the Syk-dependent NF-κB pathway, and of Raf-1 in the Syk-independent NF-κB signaling pathway.
Springer