[HTML][HTML] Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress
E Vladykovskaya, SD Sithu, P Haberzettl… - Journal of biological …, 2012 - ASBMB
Lipid peroxidation products, such as 4-hydroxy-trans-2-nonenal (HNE), cause endothelial
activation, and they increase the adhesion of the endothelium to circulating leukocytes.
Nevertheless, the mechanisms underlying these effects remain unclear. We observed that in
HNE-treated human umbilical vein endothelial cells, some of the protein-HNE adducts
colocalize with the endoplasmic reticulum (ER) and that HNE forms covalent adducts with
several ER chaperones that assist in protein folding. We also found that at concentrations …
activation, and they increase the adhesion of the endothelium to circulating leukocytes.
Nevertheless, the mechanisms underlying these effects remain unclear. We observed that in
HNE-treated human umbilical vein endothelial cells, some of the protein-HNE adducts
colocalize with the endoplasmic reticulum (ER) and that HNE forms covalent adducts with
several ER chaperones that assist in protein folding. We also found that at concentrations …