Activation of microglial G‑protein-coupled receptor 30 protects neurons against excitotoxicity through NF-κB/MAPK pathways
L Yang, L Lu, J Yue, X Wang, J Qi, F Yang, S Liu - Brain Research Bulletin, 2021 - Elsevier
Neuroexcitotoxicity is a common feature in neuronal damage and neurodegenerative
diseases. Our previous studies have confirmed that neuronal and astrocytic G‑protein-
coupled receptor 30 (GPR30) play a key role in neuroprotection in vivo and in vitro.
Microglia are considered as immune cells in the central nervous system. However, the role
of microglial GPR30 in neuroprotection against neuroexcitotoxicity remained unclear. In this
study, MTT, Western blot, immunocytochemical staining, phagocytosis assay and wound …
diseases. Our previous studies have confirmed that neuronal and astrocytic G‑protein-
coupled receptor 30 (GPR30) play a key role in neuroprotection in vivo and in vitro.
Microglia are considered as immune cells in the central nervous system. However, the role
of microglial GPR30 in neuroprotection against neuroexcitotoxicity remained unclear. In this
study, MTT, Western blot, immunocytochemical staining, phagocytosis assay and wound …