[HTML][HTML] G protein-coupled receptor 30 (GPR30) forms a plasma membrane complex with membrane-associated guanylate kinases (MAGUKs) and protein kinase A …
S Broselid, KA Berg, TA Chavera, R Kahn… - Journal of Biological …, 2014 - ASBMB
GPR30, or G protein-coupled estrogen receptor, is a G protein-coupled receptor reported to
bind 17β-estradiol (E 2), couple to the G proteins G s and G i/o, and mediate non-genomic
estrogenic responses. However, controversies exist regarding the receptor pharmacological
profile, effector coupling, and subcellular localization. We addressed the role of the type I
PDZ motif at the receptor C terminus in receptor trafficking and coupling to cAMP production
in HEK293 cells and CHO cells ectopically expressing the receptor and in Madin-Darby …
bind 17β-estradiol (E 2), couple to the G proteins G s and G i/o, and mediate non-genomic
estrogenic responses. However, controversies exist regarding the receptor pharmacological
profile, effector coupling, and subcellular localization. We addressed the role of the type I
PDZ motif at the receptor C terminus in receptor trafficking and coupling to cAMP production
in HEK293 cells and CHO cells ectopically expressing the receptor and in Madin-Darby …