[HTML][HTML] The protease‐activated receptor 4 Ala120Thr variant alters platelet responsiveness to low‐dose thrombin and protease‐activated receptor 4 desensitization …
Essentials• The rs773902 SNP results in differences in platelet protease‐activated receptor
(PAR4) function.• The functional consequences of rs773902 were analyzed in human
platelets and stroke patients.• rs773902 affects thrombin‐induced platelet function, PAR4
desensitization, stroke association.• Enhanced PAR4 Thr120 effects on platelet function are
blocked by ticagrelor. Summary: Background F2RL3 encodes protease‐activated receptor
(PAR) 4 and harbors an A/G single‐nucleotide polymorphism (SNP)(rs773902) with racially …
(PAR4) function.• The functional consequences of rs773902 were analyzed in human
platelets and stroke patients.• rs773902 affects thrombin‐induced platelet function, PAR4
desensitization, stroke association.• Enhanced PAR4 Thr120 effects on platelet function are
blocked by ticagrelor. Summary: Background F2RL3 encodes protease‐activated receptor
(PAR) 4 and harbors an A/G single‐nucleotide polymorphism (SNP)(rs773902) with racially …