[HTML][HTML] A Gi‐independent mechanism mediating Akt phosphorylation in platelets
Background: The serine‐threonine kinase Akt plays an important role in regulating platelet
activation. Stimulation of platelets with various agonists results in Akt activation as indicated
by Akt phosphorylation. However, the mechanisms of Akt phosphorylation in platelets are
not completely understood. Objectives and Methods: We used P2Y 12 knockout mice to
address the role of P2Y 12 in Akt phosphorylation in response to thrombin receptors in
platelets. Results: Thrombin or the PAR4 thrombin receptor peptide AYPGKF at high …
activation. Stimulation of platelets with various agonists results in Akt activation as indicated
by Akt phosphorylation. However, the mechanisms of Akt phosphorylation in platelets are
not completely understood. Objectives and Methods: We used P2Y 12 knockout mice to
address the role of P2Y 12 in Akt phosphorylation in response to thrombin receptors in
platelets. Results: Thrombin or the PAR4 thrombin receptor peptide AYPGKF at high …