[HTML][HTML] Human and mouse PAR4 are functionally distinct receptors: Studies in novel humanized mice
SA Renna, JV Michael, X Kong, L Ma, P Ma… - Journal of Thrombosis …, 2022 - Elsevier
Background Human and mouse platelets both express protease‐activated receptor (PAR) 4
but sequence alignment reveals differences in several functional domains. These
differences may result in functional disparities between the receptors which make it difficult
to translate PAR4 studies using mice to human platelet physiology. Objectives To generate
transgenic mice that express human, but not mouse, PAR4 and directly compare human and
mouse PAR4 function in the same platelet environment. Methods Transgenic mice were …
but sequence alignment reveals differences in several functional domains. These
differences may result in functional disparities between the receptors which make it difficult
to translate PAR4 studies using mice to human platelet physiology. Objectives To generate
transgenic mice that express human, but not mouse, PAR4 and directly compare human and
mouse PAR4 function in the same platelet environment. Methods Transgenic mice were …