[HTML][HTML] Activation of peroxisome proliferator-activated receptor α induces lysosomal biogenesis in brain cells: implications for lysosomal storage disorders
A Ghosh, M Jana, K Modi, FJ Gonzalez, KB Sims… - Journal of Biological …, 2015 - ASBMB
Lysosomes are ubiquitous membrane-enclosed organelles filled with an acidic interior and
are central to the autophagic, endocytic, or phagocytic pathway. In contrast to its classical
function as the waste management machinery, lysosomes are now considered to be an
integral part of various cellular signaling processes. The diverse functionality of this single
organelle requires a very complex and coordinated regulation of its activity with transcription
factor EB (TFEB), a master regulator of lysosomal biogenesis, at its core. However …
are central to the autophagic, endocytic, or phagocytic pathway. In contrast to its classical
function as the waste management machinery, lysosomes are now considered to be an
integral part of various cellular signaling processes. The diverse functionality of this single
organelle requires a very complex and coordinated regulation of its activity with transcription
factor EB (TFEB), a master regulator of lysosomal biogenesis, at its core. However …