Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis
KM Brennan, F Galban-Horcajo, S Rinaldi… - Journal of …, 2011 - Elsevier
The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to
establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma
since its first description over forty years ago. We now report that the use of lipid arrays
identifies heteromeric complexes of myelin derived lipids as a prominent target for this
intrathecal B cell response.
establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma
since its first description over forty years ago. We now report that the use of lipid arrays
identifies heteromeric complexes of myelin derived lipids as a prominent target for this
intrathecal B cell response.