[HTML][HTML] Differential effects of fingolimod and natalizumab on B cell repertoires in multiple sclerosis patients
MC Kowarik, D Astling, G Lepennetier, A Ritchie… - …, 2021 - Elsevier
Natalizumab and fingolimod are effective multiple sclerosis (MS) therapies that disrupt
lymphocyte migration but have differential effects on B cell maturation and trafficking. We
investigated their effects on peripheral blood (PB) and cerebrospinal fluid (CSF) B cell
repertoires using next-generation deep sequencing. Paired CSF and PB B cell subsets
(naïve, CD27+ memory, and CD27− IgD− double-negative B cells and plasmablasts) were
collected by applying flow cytometry at baseline and after 6 months of treatment and their …
lymphocyte migration but have differential effects on B cell maturation and trafficking. We
investigated their effects on peripheral blood (PB) and cerebrospinal fluid (CSF) B cell
repertoires using next-generation deep sequencing. Paired CSF and PB B cell subsets
(naïve, CD27+ memory, and CD27− IgD− double-negative B cells and plasmablasts) were
collected by applying flow cytometry at baseline and after 6 months of treatment and their …