Old and new inhibitors of quinone reductase 2
G Ferry, S Hecht, S Berger, N Moulharat, F Coge… - Chemico-biological …, 2010 - Elsevier
Quinone reductase 2 is a cytosolic enzyme which catalyses the reduction of quinones, such
as menadione and coenzymes Q. Despite a relatively close sequence-based resemblance
to NAD (P) H: quinone oxidoreductase 1 (QR1), it has many different features. QR2 is the
third melatonin binding site (MT3). It is inhibited in the micromolar range by melatonin, and
does not accept conventional phosphorylated nicotinamides as hydride donors. QR2 has a
powerful capacity to activate quinones leading to unexpected toxicity situations. In the …
as menadione and coenzymes Q. Despite a relatively close sequence-based resemblance
to NAD (P) H: quinone oxidoreductase 1 (QR1), it has many different features. QR2 is the
third melatonin binding site (MT3). It is inhibited in the micromolar range by melatonin, and
does not accept conventional phosphorylated nicotinamides as hydride donors. QR2 has a
powerful capacity to activate quinones leading to unexpected toxicity situations. In the …