Assessing burrowing, nest construction, and hoarding in mice

R Deacon - JoVE (Journal of Visualized Experiments), 2012 - jove.com
Deterioration in the ability to perform" Activities of daily living"(ADL) is an early sign of
Alzheimer's disease (AD). Preclinical behavioural screening of possible treatments for AD
currently largely focuses on cognitive testing, which frequently demands expensive
equipment and lots of experimenter time. However, human episodic memory (the most
severely affected aspect of memory in AD) is different to rodent memory, which seems to be
largely non-episodic. Therefore the present ways of screening for new AD treatments for AD …