4-Hydroxy-2-nonenal: a product and mediator of oxidative stress
K Uchida - Progress in lipid research, 2003 - Elsevier
The onset of lipid peroxidation within cellular membranes is associated with changes in their
physiochemical properties and with the impairment of enzymatic functions located in the
membrane environment. There is increasing evidence that aldehydic molecules generated
endogenously during the process of lipid peroidation are causally involved in most of the
pathophysiological effects associated with oxidative stress in cells and tissues. 4-Hydroxy-2-
nonenal (HNE), among them, is believed to be largely responsible for cytopathological …
physiochemical properties and with the impairment of enzymatic functions located in the
membrane environment. There is increasing evidence that aldehydic molecules generated
endogenously during the process of lipid peroidation are causally involved in most of the
pathophysiological effects associated with oxidative stress in cells and tissues. 4-Hydroxy-2-
nonenal (HNE), among them, is believed to be largely responsible for cytopathological …