Association of deep gray matter damage with cortical and spinal cord degeneration in primary progressive multiple sclerosis
S Ruggieri, M Petracca, A Miller, S Krieger… - JAMA …, 2015 - jamanetwork.com
Importance The investigation of cortical gray matter (GM), deep GM nuclei, and spinal cord
damage in patients with primary progressive multiple sclerosis (PP-MS) provides insights
into the neurodegenerative process responsible for clinical progression of MS. Objective To
investigate the association of magnetic resonance imaging measures of cortical, deep GM,
and spinal cord damage and their effect on clinical disability. Design, Setting, and
Participants Cross-sectional analysis of 26 patients with PP-MS (mean age, 50.9 years; …
damage in patients with primary progressive multiple sclerosis (PP-MS) provides insights
into the neurodegenerative process responsible for clinical progression of MS. Objective To
investigate the association of magnetic resonance imaging measures of cortical, deep GM,
and spinal cord damage and their effect on clinical disability. Design, Setting, and
Participants Cross-sectional analysis of 26 patients with PP-MS (mean age, 50.9 years; …