RNA transport and local translation in neurodevelopmental and neurodegenerative disease
MS Fernandopulle, J Lippincott-Schwartz… - Nature …, 2021 - nature.com
MS Fernandopulle, J Lippincott-Schwartz, ME Ward
Nature neuroscience, 2021•nature.comNeurons decentralize protein synthesis from the cell body to support the active metabolism
of remote dendritic and axonal compartments. The neuronal RNA transport apparatus,
composed of cis-acting RNA regulatory elements, neuronal transport granule proteins, and
motor adaptor complexes, drives the long-distance RNA trafficking required for local protein
synthesis. Over the past decade, advances in human genetics, subcellular biochemistry, and
high-resolution imaging have implicated each member of the apparatus in several …
of remote dendritic and axonal compartments. The neuronal RNA transport apparatus,
composed of cis-acting RNA regulatory elements, neuronal transport granule proteins, and
motor adaptor complexes, drives the long-distance RNA trafficking required for local protein
synthesis. Over the past decade, advances in human genetics, subcellular biochemistry, and
high-resolution imaging have implicated each member of the apparatus in several …
Abstract
Neurons decentralize protein synthesis from the cell body to support the active metabolism of remote dendritic and axonal compartments. The neuronal RNA transport apparatus, composed of cis-acting RNA regulatory elements, neuronal transport granule proteins, and motor adaptor complexes, drives the long-distance RNA trafficking required for local protein synthesis. Over the past decade, advances in human genetics, subcellular biochemistry, and high-resolution imaging have implicated each member of the apparatus in several neurodegenerative diseases, establishing failed RNA transport and associated processes as a unifying pathomechanism. In this review, we deconstruct the RNA transport apparatus, exploring each constituent’s role in RNA localization and illuminating their unique contributions to neurodegeneration.
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