Altered type 1 interferon responses in alloimmunized and nonalloimmunized patients with sickle cell disease
E Madany, J Lee, C Halprin, J Seo, N Baca… - …, 2021 - Wiley Online Library
Patients with sickle cell disease (SCD) have a high prevalence of RBC alloimmunization.
However, underlying mechanisms are poorly understood. Given that proinflammatory type 1
interferons (IFNα/β) and interferon stimulated genes (ISGs) promote alloimmunization in
mice, we hypothesized that IFNα/β may contribute to the increased frequency of
alloimmunization in patients with SCD. To investigate this, expression of ISGs in blood
leukocytes and peripheral blood mononuclear cells (PBMCs) of previously transfused SCD …
However, underlying mechanisms are poorly understood. Given that proinflammatory type 1
interferons (IFNα/β) and interferon stimulated genes (ISGs) promote alloimmunization in
mice, we hypothesized that IFNα/β may contribute to the increased frequency of
alloimmunization in patients with SCD. To investigate this, expression of ISGs in blood
leukocytes and peripheral blood mononuclear cells (PBMCs) of previously transfused SCD …
[CITATION][C] Type 1 Interferon Gene Signatures in RBC Alloimmunized and Non-Alloimmunized Patients with Sickle Cell Disease
E Madany, JY Lee, CE Halprin, CA Hayes… - 2021 Virtual Annual …, 2021 - aabb.confex.com
