1: Arachidonic Acid Metabolism in Inflammation and Hypersensitivity Reactions: A Brief Introduction
CL Malmsten - Cephalalgia, 1986 - journals.sagepub.com
CL Malmsten
Cephalalgia, 1986•journals.sagepub.comThe initial step-and in most cases probably also the rate-limiting step-is the liberation of free
acid from the esterified phospholipid pool of the cell. Liberation is activated by surface
stimulation of the cells and this process in turn activates a phospholipase activity.
Unfortunately, the mechanism of this enzyme has still to be eludicated. Factors that cause
release of arachidonic acid vary between different cells and tissues. In platelets, eg
subendothelial tissue, collagen, thrombin, ADP, epinephrine, antigen-antibody complexes …
acid from the esterified phospholipid pool of the cell. Liberation is activated by surface
stimulation of the cells and this process in turn activates a phospholipase activity.
Unfortunately, the mechanism of this enzyme has still to be eludicated. Factors that cause
release of arachidonic acid vary between different cells and tissues. In platelets, eg
subendothelial tissue, collagen, thrombin, ADP, epinephrine, antigen-antibody complexes …
The initial step-and in most cases probably also the rate-limiting step-is the liberation of free acid from the esterified phospholipid pool of the cell. Liberation is activated by surface stimulation of the cells and this process in turn activates a phospholipase activity. Unfortunately, the mechanism of this enzyme has still to be eludicated.
Factors that cause release of arachidonic acid vary between different cells and tissues. In platelets, eg subendothelial tissue, collagen, thrombin, ADP, epinephrine, antigen-antibody complexes, dead or alive bacteria and virus might activate this reaction. In leukocytes, bacteria wall peptides and other chemo-attractants, ionophores, urate-crystals and serum-treated zymosan are some active agents in this aspect.
Sage Journals