COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization
BACKGROUND: Mechanical injury to the skin by scratching is an important feature of atopic
dermatitis (AD). OBJECTIVE: To investigate the role of COX-2 in allergic skin inflammation
elicited by epicutaneous (EC) sensitization via introduction of ovalbumin through shaved
tape-stripped skin. METHODS: COX-2 mRNA was measured by quantitative PCR, and COX-
2 protein was measured by Western blotting. We investigated the effect of administration of
the COX-2 selective inhibitor NS-398 during EC sensitization with ovalbumin in a mouse …
dermatitis (AD). OBJECTIVE: To investigate the role of COX-2 in allergic skin inflammation
elicited by epicutaneous (EC) sensitization via introduction of ovalbumin through shaved
tape-stripped skin. METHODS: COX-2 mRNA was measured by quantitative PCR, and COX-
2 protein was measured by Western blotting. We investigated the effect of administration of
the COX-2 selective inhibitor NS-398 during EC sensitization with ovalbumin in a mouse …
