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Opening windows for bone remodeling through a SLIT
Jameel Iqbal, … , Se-Min Kim, Mone Zaidi
Jameel Iqbal, … , Se-Min Kim, Mone Zaidi
Published April 2, 2018; First published March 5, 2018
Citation Information: J Clin Invest. 2018;128(4):1255-1257. https://doi.org/10.1172/JCI120325.
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Category: Commentary

Opening windows for bone remodeling through a SLIT

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Abstract

Bone formation and resorption are tightly coupled, and dysfunction of either process leads to bone diseases, such as osteoporosis. Bone-forming agents have been explored clinically to increase bone density; however, long-term efficacy of these strategies is limited due to the accompanying increase in resorption in response to increased bone formation. Axonal guidance molecules have recently been shown to regulate formation-resorption coupling and thus have the potential for osteoporosis therapy. In this issue of the JCI, Kim et al. demonstrate that osteoclast-secreted SLIT3 influences bone formation and resorption by promoting osteoblast migration and suppressing osteoclast differentiation. Activation of SLIT3/ROBO signaling in ovariectomized mice increased bone mass, suggesting that SLIT3 should be further explored as a therapeutic target.

Authors

Jameel Iqbal, Tony Yuen, Se-Min Kim, Mone Zaidi

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ISSN: 0021-9738 (print), 1558-8238 (online)

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