Human regulatory B cells in health and disease: therapeutic potential
Claudia Mauri and Madhvi Menon
Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom.
Address correspondence to: Claudia Mauri, Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, United Kingdom. Phone: 44.0.2031082155; E-mail: c.mauri@ucl.ac.uk.
Find articles by Mauri, C. in: JCI | PubMed | Google Scholar
Centre for Rheumatology, Division of Medicine, University College London, London, United Kingdom.
Address correspondence to: Claudia Mauri, Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, United Kingdom. Phone: 44.0.2031082155; E-mail: c.mauri@ucl.ac.uk.
Find articles by Menon, M. in: JCI | PubMed | Google Scholar
First published March 1, 2017 - More info
J Clin Invest. 2017;127(3):772–779. doi:10.1172/JCI85113.
Copyright © 2017, American Society for Clinical Investigation
Regulatory B cells (Bregs) modulate immune responses predominantly, although not exclusively, via the release of IL-10. The importance of human Bregs in the maintenance of immune homeostasis comes from a variety of immune-related pathologies, such as autoimmune diseases, cancers, and chronic infections that are often associated with abnormalities in Breg numbers or function. A continuous effort toward understanding Breg biology in healthy individuals will provide new opportunities to develop Breg immunotherapy that could prove beneficial in treating various immune-mediated pathologies. In this Review, we discuss findings regarding human Bregs, including their mechanisms of suppression and role in different disease settings. We also propose several therapeutic strategies targeting Bregs for better management of immune disorders.
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Copyright © 2017 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)